1H-PYRAZOLO[4,3-C]PYRIDINE, 6-CHLORO-3-IODO-

1H-PYRAZOLO[4,3-C]PYRIDINE, 6-CHLORO-3-IODO- - Names and Identifiers

Name	1H-Pyrazolo[4,3-c]pyridine, 6-chloro-3-iodo-
Synonyms	EOS-62186 6-chloro-3-iodo-2H-pyrazolo[4,3-c]pyridine 6-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine 1H-PYRAZOLO[4,3-C]PYRIDINE, 6-CHLORO-3-IODO- 1H-Pyrazolo[4,3-c]pyridine, 6-chloro-3-iodo-
CAS	1260672-72-7
InChIKey	METUREDHGCAEJK-UHFFFAOYSA-N

1H-PYRAZOLO[4,3-C]PYRIDINE, 6-CHLORO-3-IODO- - Physico-chemical Properties

Molecular Formula	C6H3ClIN3
Molar Mass	279.47
Density	2.284±0.06 g/cm3(Predicted)
Boling Point	435.2±40.0 °C(Predicted)
pKa	8.51±0.40(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C

1H-PYRAZOLO[4,3-C]PYRIDINE, 6-CHLORO-3-IODO- - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed

1H-PYRAZOLO[4,3-C]PYRIDINE, 6-CHLORO-3-IODO- - Introduction

6-Chloro-3-iodo-1H-pyrazolo [4,3-c] pyridine is an organic compound whose chemical formula is C8H3ClIN2. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 6-Chloro-3-iodo-1H-pyrazolo [4,3-c] pyridine is a solid, often yellow or yellowish green crystal.
-Melting point: about 140-150°C.
-Solubility: Soluble in common organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane.

Use:
-6-Chloro-3-iodo-1H-pyrazolo [4,3-c] pyridine is commonly used in organic synthesis reactions, such as catalytic reduction, aromatization, halogenation and cycloaddition reactions.
-It can also be used as a fluorescent probe to detect oxidative stress and redox reactions in the environment.

Method:
The preparation method of 6-chloro-3-iodo-1H-pyrazolo [4,3-c] pyridine is more complicated. The following is one of the common preparation methods:
1. First, 2,6-dichloro-3-iodopyridine was used as a starting material.
2. The starting material is reacted with phosphorus pentachloride to obtain 2,6-dichloro-3-iodo-4-pyridone.
3. Condensation of 4-pyridone with ethyl acetone and cyclization under alkaline conditions to form 6-chloro-3-iodo-1H-pyrazolo [4,3-c] pyridine.

Safety Information:
-6-Chloro-3-iodo-1H-pyrazolo [4,3-c] pyridine is an organic compound that may cause health and environmental hazards.
-During handling and storage, take necessary safety measures, such as wearing chemical protective gloves, goggles and protective clothing.
-Avoid inhaling its dust or vapor, avoid contact with skin and eyes.
-When using, it should be operated in a well-ventilated place and avoid contact with fire sources.
-In the event of accidental exposure or discomfort, seek medical attention immediately and bring the compound's safety data sheet to provide the appropriate information to the doctor.

Last Update：2024-04-10 22:29:15